7th Workshop

November 2015 – Munich, Germany

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Monday, 9 November 2015

Session 1: Radiation Protection Research in Europe

Nikolaus Blum, Administrative Director, Helmholtz Zentrum München, Germany

Rita Lecbychova, Head of Unit in charge of Fission Energy
Directorate General for Research and Innovation, European Commission, Belgium: Integrating radiation protection research at EU level”

Axel Böttger, Head of Division RS II 2 – Fundamental Aspects of Radiological Protection, Federal Ministry for the Environment, Nature Conservation, Building and Reactor Safety, Germany:
“Expectations in MELODI from the German regulatory authority”

Wilfried Kraus, Director, Directorate Sustainability, Climate and Energy, Federal Ministry of Education and Research, Germany:
„Maintaining and enhancing competence in radiation protection – The German radiation research initiative”

Werner Rühm, Scientific Secretary, ICRP Committee 1, Helmholtz Zentrum München, Germany: Scientific Needs of ICRP for the Next Generation of Radiation Protection”

Jacques Repussard, Chair of MELODI, Institut de Radioprotection et de Sûreté Nucléaire, France

Thomas Jung, Head of Department of Radiation Protection and Health, Federal Office of Radiation Protection, Germany:
“CONCERT – Joint programming to advance radiation protection research in Europe”

Session 2: Low-Dose Radiation Research: Where are we?

Sisko Salomaa, STUK – Radiation and Nuclear Safety Authority, Finland: DoReMi
Simon Bouffler, Public Health England, UK: RISK-IR
Peter Jacob, Helmholtz Zentrum München, Germany: EpiRadBio
John Harrison, Public Health England, UK: SOLO


Public Lecture

Pieter Monsieurs, Belgian Nuclear Research Centre, Belgium: Next Generation Sequencing


Tuesday, 10 November 2015

Session 2: Low-Dose Radiation Research: Where are we? (continued)

Andrea Ottolenghi, University Pavia, Italy: ANDANTE
Mike Atkinson, Helmholtz Zentrum München, Germany: PROCARDIO
Rafi Benotmane, Belgian Nuclear Research Centre, Belgium: CEREBRAD
Ausrele Kesminiene, International Agency for Research on Cancer, France: EPI-CT

Session 3: Low-dose risk

Horst Zitzelsberger, Helmholtz Zentrum München, Germany:
Molecular landscape of papillary thyroid carcinomas from the UkrAm cohort and modelling of carcinogenesis
Roy Shore, Radiation Effects Research Foundation, Japan: Radiation risk inference at low dose and low dose rate exposure for radiological protection purposes
Tatjana Paunesku, Northwestern University, IL, USA:
Large-scale animal studies for evaluation of dose and dose rate responses
Helmut Schöllnberger, Helmholtz Zentrum München, Germany:
Dose-responses for cerebrovascular and heart disease in atomic bomb survivors – an analysis involving multi-model inference techniques
Dominique Laurier on behalf of the INWORKS consortium. University of North Carolina, NC, USA: Risk of cancer mortality in an international study of nuclear workers (INWORKS)

Session 4: Factors affecting individual risk

Dominique Laurier on behalf of the INWORKS consortium. Institut de Radioprotection et de Sûreté Nucléaire, France: Risk of leukaemia, lymphoma, and multiple myeloma in an international study of nuclear workers (INWORKS)
Markus Eidemüller, Helmholtz Zentrum München, Germany:
Individual risk factors for breast cancer and risk transfer among populations
Aleksandra Fucic, Institute for Medical Research and Occupational Health, Zagreb, Croatia: Acentric fragments are associated with cancer risk in subjects occupationally or accidentally exposed to ionizing radiation: Re-analysis of a large European pooled cohort
Hanane Derradji, Belgian Nuclear Research Centre, Belgium:
Changes induced by radiation and iodine deficiency in thyroid cells

Session 5: ALLIANCE-MELODI cross cutting themes

Béatrice Gagnaire, Institut de Radioprotection et de Sûreté Nucléaire, France: Biomarkers of exposure and effects: Are they useful tools to understand radiation sensitivity in living organisms?
Karim Fahmy, Helmholtz-Zentrum Dresden-Rossendorf, Germany: Metabolic heat: an in
vivo signature of low dose radiation sensitivity
Nele Horemans, Belgian Nuclear Research Centre, Belgium: Studying response of plants to radiation using biomarkers of different levels of biological complexity
Maria Antonella Tabocchini on behalf of the Cosmic Silence collaboration.
Istituto Superiore di Sanità and INFN Roma1-Gr.coll.Sanità, Roma, Italy:
The cosmic silence experiment: investigation of the molecular mechanisms involved in the biological response of living systems to environmental radiation
Hans-Christian Teien, Centre for Environmental Radioactivity, Norway:  Gamma radiation affects gene expression in early life stages of Atlantic salmon

Session 6: New biology

Munira Kadhim, Brookes University, UK:
Role of micro vesicles in non-targeted effects of radiation
Laure Sabatier, Commissariat à l’énergie atomique et aux énergies alternatives, France: Telomere length distributions in members of radio-epidemiological cohorts
S. Constantino Rosa Santos. Centro Cardiovascular da Universidade de Lisboa and Universidade de Lisboa, Portugal: Low doses of ionizing radiation enhance angiogenesis
Ann-K Olsen, Norwegian Institute of Public Health, Norway: Global gene expression and DNA methylation in testicular mouse cells after chronic exposure to continuous low dose rate gamma irradiation and Selenium deficiency

Session 7: EURADOS-MELODI cross cutting themes

Eric Blanchardon, Institut de Radioprotection et de Sûreté Nucléaire, France: Dose reconstruction in the CURE project for workers exposed to uranium
Marina Degteva, Southern Urals Biophysical Institute, Russia:
Dose reconstruction in the SOLO project for Mayak workers and former residents of the Techa River area
E. Schmitt, Helmholtz Zentrum München, Germany:
PARTRAC – Recent developments towards medical applications

Roger Harrison on behalf of EURADOS WG9:Out-of-field dosimetry in radiotherapy for input to epidemiological studies

Wednesday, 11 November 2015

Session 8: Infrastructures, education and training

Vere Smyth, University Pavia, Italy: Education and training
Laure Sabatier, Commissariat à l’énergie atomique et aux énergies alternatives, France: Short introduction to the topic ‘Infrastructures’
Michael Raess, Helmholtz Zentrum München, Germany: The Intrafrontier Research Infrastructure
U. Kulka, on behalf of the RENEB consortium. Bundesamt fuer Strahlenschutz, Germany: RENEB – The Future
Siamak Haghdoost, Stockholm University, Sweden:
Setups for exposing cells and animals to gamma radiation at low and high dose rate and to mixed beams of low and high LET radiation

Session 9: NERIS-MELODI cross cutting themes

Wolfgang Weiss, Freiburg, Germany:
Thyroid cancer surveys after nuclear emergencies
Jean-René Jourdain, Institut de Radioprotection et de Sûreté Nucléaire, France: PRIODAC, a project to determine the modalities and side effects of multiple administrations of stable iodine to protect people chronically exposed to radioactive iodine
Wolfgang Raskob, Karlsruhe Institute of Technology, Germany: Integration of iodine tablet distribution into countermeasures strategies
F. Gering, German Federal Office for Radiation Protection, Oberschleißheim, Germany:
Recent developments regarding iodine thyroid blocking in Switzerland and Germany

Session 10: Radiation effects on stem cells

Kevin Prise, University Belfast, UK: Breast stem cells and radiation
Umberto Galderisi, Seconda Università di Napoli, Italy: Functions and secretome activity of human mesenchymal stem cells are affected by low dose radiation treatment
Rhona M. Anderson, Medical Research Council, UK. 2Brunel University London, UK:
α-particle-induced complex chromosome exchanges transmitted through extra-thymic lymphopoiesis in vitro
Nynke Hosper, University of Groningen, The Netherlands: Radiation induced carcinogenesis of thyroid gland stem cells

Session 11: Medical-MELODI cross cutting themes

R Tamarat, Institute for Radioprotection and Nuclear Safety, France:
Circulating microparticles associate to severe radiation proctitis consecutive to abdomino- pelvic radiotherapy
Iuliana Toma-Dasu, Stockholms Universitet and Karolinska Institutet, Sweden: Risk of secondary cancer induced by radiotherapy
Wolfram Stiller, Universitätsklinikum Heidelberg, Germany:
CT technology developments: what are the benefits for radiation protection?
John Damilakis. University of Crete, Greece: 3D patient-specific and equipment-specific dosimetry in CT: from conceptus to the adolescent
C. Hoeschen, Helmholtz Zentrum München and Otto-von-Guericke University, Germany: Common Strategic Research Agenda for Radiation Protection in Medicine by the European Medical Associations representing Ionising Radiation Applications in Medicine
Graciano Paulo, Coimbra Health School, Portugal: Diagnostic Reference Levels in plain radiography for paediatric imaging: a Portuguese study

Session 12: Concluding session

Contributions of Sessions 3 through 11 to MELODI SRA
Simon Bouffler, Public Health England, UK: MELODI Workshop 2016
Mike Atkinson, Helmholtz Zentrum München, Germany: Concluding Remarks




15.30 End of Workshop